17-03-14 Yoshimori T¶
1-2% of prot --> lysis
80% of AA --> biosynthesis of protein
selective
atg 1-14
core atg
autophagosome
lc3 (atg8)
Kabeya, 2000, Embo J
from where ?¶
Hayashi, 2009, Nat Cell Biol
cradle model
er vs. mito
contact site mito er
ca, lipid
iii pi3 k
xenophagy¶
selectivity
Kageyama, 2011, Mol Biol Cell
enodosme
autophagy recognize damaged endosome
lysophagy¶
Maejima, 2013, Embo J
damaged lysosome
Hr-UAemia nephliitis
lysosome fusion w/ autophagosome¶
inpp5e
Hasegawa, 2016, Embo J
Joubert synd
Bielas, 2009, Nat Genet
cd, pd senda synd viei synd , cancer, joubert synd
Fatty liver¶
Tanaka, 2016, Hepato
rubicon
fatty diet incrased rubicon fatty liver
acquired
Melanosome¶
QA¶
Virus infexn¶
polio autophagosome
PD¶
pink1 park